Anti-α-E-Catenin antibody produced in rabbit

MFCD05665180

NA.41

The catenins (α, β, γ) are cytoplasmic proteins found in varying abundance in many developing and adult tissues.
α-E-Catenin is a predominant subtype of α-catenin. It is widely expressed but at low levels in the nervous system. Alternative spliced variants of α-E-Catenin include α1- and α2-E-catenin.

synthetic peptide corresponding to a region located near the C-terminus of human α-E-catenin (amino acids 873-887). This sequence is identical in mouse and Xenopus α-E-catenin. It is not found in α-N-catenin, β-catenin, and γ-catenin.

Anti-α-E-Catenin antibody produced in rabbit has been used in western blotting and immunocytochemistry.

Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion adherins. The association of catenins to cadherins produces a complex, which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion, transduction of cell-cell contact positional signals to the cell interior, and may play a crucial role in cell differentiation. The linkage of the epithelial cadherin /uvomorulin to actin is essential for the cell binding function of this cadherin. α-Catenin (CAP102, 102 kDa), originally described as an E-cadherin associated protein, has been shown to associate with other members of the cadherin family members, N-cadherin and P-cadherin. Within its conserved region α-catenin shows 30% identity to vinculin.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

antigen 102 kDa

canine, rat, human

immunocytochemistry: 1:200 using methanol-fixed, dog MDCK and human MCF7 cellc
microarray: suitable
western blot: 1:1,000 using whole cell extract of human epidermal carcinoma A431 cell line and cytosolic fraction of rat embryonic brain.

P35221

dry ice

−20℃

human ... CTNNA1(1495)
rat ... Ctnna1(307505)

200 μL in glass insert

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12 - Non Combustible Liquids

WGK 2

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