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AMTB hydrate

产品编号:3341883
规格:≥98% (HPLC)
CAS NO:926023-82-7
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
33418835 MG1850
334188325 MG5160
产品别名

926023-82-7

AMTB hydrate

N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C23H26N2O2S·HCl · xH2O
Molecular weight
430.99 (anhydrous basis)
PubChem Substance ID【PubChem化学物质编号】
329825160
NACRES
NA.77
Application【应用】
AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.
Biochem/physiol Actions【生化/生理作用】
AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.
AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
color【颜色】
white to tan
solubility【溶解性】
DMSO: ≥10 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
InChI
1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
InChI key
RTYVTAQFASBIDN-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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