Alantolactone

C₁₅H₂₀O₂

232.32

208-899-3

MFCD00274568

329825410

NA.77

Alantolactone is a compound produced by Inula helenium. Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells.

Alantolactone has been used:

• in cell viability assay
• to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
• in assessment of degranulation

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

100

≥98% (HPLC)

powder

desiccated
protect from light

white to beige

DMSO: 15 mg/mL (clear solution)

−20℃

C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12

1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1

PXOYOCNNSUAQNS-AGNJHWRGSA-N

5, 25 mg in glass bottle

GHS07

Warning

H317

P261 - P272 - P280 - P333 + P313 - P362 + P364 - P501

Skin Sens. 1

13 - Non Combustible Solids

WGK 3