7-氨基头孢烷酸

C₁₀H₁₂N₂O₅S

272.28

622637

213-485-0

MFCD00005177

24851470

NA.22

化学结构:β-内酰胺

细菌(金黄色葡萄球菌)β-内酰胺酶的有效抑制剂。
7-Aminocephalosporanic acid (7-ACA) can be used as a starting material to synthesize:

• Cefotaxime by acylation reaction with S-benzothiazol-2-yl(2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM) in the presence of triethylamine.
• Cefpodoxime proxetil, a third-generation antibiotic via cefotaxime intermediate.
• Sodium 3′-substituted cephalosporanate sulfone derivatives as potential inhibitors of β-lactamase.

200

98%

powder

[α]19/D +90°, c = 0.5 in KH₂PO₄/trace NaOH

reaction type: solution phase peptide synthesis

>300 ℃ (lit.)

Gram-positive bacteria

peptide synthesis

cell wall synthesis | interferes

2-8℃

[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O

1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1

HSHGZXNAXBPPDL-HZGVNTEJSA-N

5 g in glass bottle

GHS08

Danger

H317 - H334

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Resp. Sens. 1 - Skin Sens. 1

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Faceshields, Gloves