1H-苯并三唑-1-基氧三吡咯烷基六氟磷酸盐

C₁₈H₂₈N₆OP · PF₆

520.39

3584612

MFCD00077411

329749882

NA.22

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:

• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

BOP 偶联剂类似物，不产生致癌副产物 HMPA。

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

200

purum

≥97.0% (TLC)

reaction type: Coupling Reactions

~150 ℃
154-156 ℃ (dec.) (lit.)

peptide synthesis

2-8℃

F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5

1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1

VIAFLMPQBHAMLI-UHFFFAOYSA-N

GHS07,GHS09

Warning

H302 - H317 - H410

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1

13 - Non Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves