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Zotepine
产品编号:3262065
CAS NO:26615-21-4
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
326206510 MG1130
326206550 MG3260
产品别名

26615-21-4

佐替平

Zotepine

2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H18ClNOS
Molecular weight
331.86
MDL number
MFCD00868143
PubChem Substance ID【PubChem化学物质编号】
329831602
NACRES
NA.77
Application【应用】
Zotepine has been used as an anti-psychotic agent:
  • in biophysical studies with serotonin 2A receptor (5-HT2AR)
  • to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
  • to study its protective effects on the human embryonic kidney (HEK cells)

Biochem/physiol Actions【生化/生理作用】
Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Zotepine is an atypical antipsychotic.
Features and Benefits【特点和优势】
This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes【其他说明】
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. Z0877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
产品性质
Assay【测定】
>98% (HPLC)
Quality Level【质量水平】
100
form【形式】
powder
color【颜色】
white to off-white
solubility【溶解性】
DMSO: ≥20 mg/mL
originator【创始人】
Astellas
storage temp.【储存温度】
room temp
SMILES string
CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
InChI
1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChI key
HDOZVRUNCMBHFH-UHFFFAOYSA-N
packaging【包装】
10, 50 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07,GHS09
Signal word【警示用语:】
Warning
Hazard Statements
H302 - H400
Precautionary Statements
P273
Hazard Classifications【危险分类】
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
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