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佐替平
Zotepine
产品别名
26615-21-4
佐替平
Zotepine
2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C18H18ClNOS |
Molecular weight | 331.86 |
MDL number | MFCD00868143 |
PubChem Substance ID【PubChem化学物质编号】 | 329831602 |
NACRES | NA.77 |
Application【应用】 | Zotepine has been used as an anti-psychotic agent:
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Biochem/physiol Actions【生化/生理作用】 | Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania. Zotepine is an atypical antipsychotic. |
Features and Benefits【特点和优势】 | This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
Other Notes【其他说明】 | Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. Z0877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. |
产品性质
Assay【测定】 | >98% (HPLC) |
Quality Level【质量水平】 | 100 |
form【形式】 | powder |
color【颜色】 | white to off-white |
solubility【溶解性】 | DMSO: ≥20 mg/mL |
originator【创始人】 | Astellas |
storage temp.【储存温度】 | room temp |
SMILES string | CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13 |
InChI | 1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3 |
InChI key | HDOZVRUNCMBHFH-UHFFFAOYSA-N |
packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
Pictograms【象形图】 | GHS07,GHS09 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H302 - H400 |
Precautionary Statements | P273 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 |
Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
WGK | WGK 3 |