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ZL006
产品别名
1181226-02-7
ZL006
4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H11Cl2NO4 |
| Molecular weight | 328.15 |
| MDL number | MFCD20527326 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825194 |
| NACRES | NA.25 |
| Biochem/physiol Actions【生化/生理作用】 | ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke. ZL006, a novel neuroprotectant, is also called as 5-(3, 5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid. It has the ability to block the interaction of neuronal nitric oxide synthase (nNOS)/postsynaptic density protein-95 (PSD-95) in co-immunoprecipitation assays of extracts from glutamate or cultured neurons and cortical brain, stimulated by ischemia. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥5 mg/mL (warmed to 60° C) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=C(Cl)C=C(Cl)C=C1CNC(C=C2)=CC(O)=C2C(O)=O |
| InChI | 1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21) |
| InChI key | RTEYSQSXRFVKTJ-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
