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WWL229

产品编号:3260277
规格:≥98% (HPLC)
CAS NO:1338575-28-2
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
32602775 MG1530
326027725 MG4490
产品别名

1338575-28-2

WWL229

4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate

2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C16H22N2O5
Molecular weight
322.36
PubChem Substance ID【PubChem化学物质编号】
329825704
Biochem/physiol Actions【生化/生理作用】
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
oil
color【颜色】
colorless to light yellow
storage temp.【储存温度】
2-8℃
SMILES string
O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
InChI
1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChI key
XVBRVSAGMWRVCK-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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