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尿激酶抑制剂筛选试剂盒
Urokinase Inhibitor Screening Kit
产品别名
尿激酶抑制剂筛选试剂盒
Urokinase Inhibitor Screening Kit
uPA Inhibitor Screening Kit
Urokinase-type Plasminogen Activator Inhibitor Screening Kit
Plasminogen Activator Inhibitor Screening Kit
纤溶酶原激活剂抑制剂筛选试剂盒
uPA抑制剂筛选试剂盒
激酶型纤溶酶原激活剂抑制剂筛选试剂盒
基本信息
| NACRES | NA.25 |
| General description【一般描述】 | Urokinase (Urokinase-type plasminogen activator, uPA, EC 3.4.21.73) is a serine protease involved in the degradation of extracellular matrix components. It cleaves the Arg-Val bond in plasminogen and converts it to plasmin. The activity of uPA is important in tumor cell proliferation and migration. Polymorphisms in uPA gene are reportedly associated with Alzheimer′s disease. |
| Principle【原理】 | The Urokinase Inhibitor Screening Kit is a rapid, simple and sensitive assay that is suitable for the screening of Urokinase inhibitors. Urokinase activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 350/ λem = 450 nm), proportional to the enzymatic activity present. |
| Components【组分】 | 组份不可单独销售 Urokinase Assay Buffer Urokinase Substrate Human Urokinase Urokinase Inhibitor; 10 mM GGACK Dihydrochloride |
产品性质
| Detection Method | fluorometric |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PLAU(5328) mouse ... PLAU(18792) rat ... PLAU(25619) |
| suitability【适用性】 | 适于筛选尿激酶抑制剂。 |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H334 |
| Precautionary Statements | P261 - P284 - P501 |
| Hazard Classifications【危险分类】 | Resp. Sens. 1 |
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
