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UCL 1684 ditrifluoroacetate hydrate
产品别名
201147-19-5
UCL 1684 ditrifluoroacetate hydrate
6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
结构式
基本信息
| Linear Formula【线性分子式】 | (C34H30N4)2+ · (C2F3O2-)2 · xH2O |
| Molecular weight | 720.66 (anhydrous basis) |
| PubChem Substance ID【PubChem化学物质编号】 | 24900684 |
| NACRES | NA.77 |
| Application【应用】 | UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries. |
| Biochem/physiol Actions【生化/生理作用】 | UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Preparation Note【制备说明】 | UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml. |
产品性质
| Quality Level【质量水平】 | 100 |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| SMILES string | [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7 |
| InChI | 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;; |
| InChI key | YROHEYZVNZITJN-DDVHGCDCSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
