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UA62784
产品别名
313367-92-9
UA62784
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H15NO3 |
| Molecular weight | 353.37 |
| MDL number | MFCD00489199 |
| PubChem Substance ID【PubChem化学物质编号】 | 329827627 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly. |
| Preparation Note【制备说明】 | UA62784 is soluble in DMSO at a concentration >2 mg/ml. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: >2 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34 |
| InChI | 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3 |
| InChI key | SVICLWPFAQYZLX-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
