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曲帕拉醇
Triparanol
产品别名
78-41-1
曲帕拉醇
Triparanol
1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H32NO2Cl |
| Molecular weight | 438.00 |
| EC number【EC 号】 | 201-115-0 |
| MDL number | MFCD00865748 |
| PubChem Substance ID【PubChem化学物质编号】 | 24724632 |
| NACRES | NA.77 |
| Application【应用】 | Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2. |
| Biochem/physiol Actions【生化/生理作用】 | Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3. Desmosterol Delta24 (D24) reductase inhibitor. |
| Preparation Note【制备说明】 | Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water. |
| Other Notes【其他说明】 | Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T5200.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| mp | 102.9-103.7 ℃ |
| solubility【溶解性】 | DMSO: 20 mg/mL H2O: insoluble alcohol: soluble olive oil: slightly soluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3 |
| InChI | 1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3 |
| InChI key | SYHDSBBKRLVLFF-UHFFFAOYSA-N |
| Gene Information | human ... DHCR24(1718), EBP(10682) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS07 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H318 |
| Precautionary Statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Dam. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
