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Terameprocol

产品编号:3249118
规格:≥98% (HPLC)
CAS NO:24150-24-1
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
324911810 MG1001
324911850 MG3310
产品别名

24150-24-1

Terameprocol

rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene

tetra-O-methyl-NDGA

EM-1421

tetramethyl NDGA

M4N

Tetra-O-methyl nordihydroguaiaretic acid

tetramethyl Nordihydroguaiaretic Acid

2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane

TMNDGA

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C22H30O4
Molecular weight
358.47
MDL number
MFCD11113155
PubChem Substance ID【PubChem化学物质编号】
329826768
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.
Terameprocol is known to reduce angiogenesis1.
Preparation Note【制备说明】
Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to off-white
solubility【溶解性】
DMSO: ≥10 mg/mL
storage temp.【储存温度】
−20℃
SMILES string
COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
InChI
1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
InChI key
ORQFDHFZSMXRLM-IYBDPMFKSA-N
packaging【包装】
10, 50 mg in glass bottle
安全信息
Pictograms【象形图】
GHS09
Signal word【警示用语:】
Warning
Hazard Statements
H410
Precautionary Statements
P273 - P501
Hazard Classifications【危险分类】
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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