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TAPI-0

产品编号:3248746
规格:≥95% (HPLC)
CAS NO:163958-73-4
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
32487461 MG3510
产品别名

163958-73-4

TAPI-0

N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide

TNF-α Protease Inhibitor-0

TNF-α Processing Inhibitor-0

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C24H32N4O5
Molecular weight
456.53
MDL number
MFCD02684279
PubChem Substance ID【PubChem化学物质编号】
329825768
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding.
TAPI-0 inhibit peptide deformylase (PDF) activity and retard the growth Chlamydia trachomatis, which is an obligate intracellular bacterium responsible for a number of human diseases.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥95% (HPLC)
form【形式】
powder
color【颜色】
white to off-white
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
SMILES string
NC([C@@](C)([H])NC([C@]([H])(CC1=CC=CC2=C1C=CC=C2)NC([C@@](CC(C)C)([H])CC(NO)=O)=O)=O)=O
InChI
1S/C24H32N4O5/c1-14(2)11-18(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-17-9-6-8-16-7-4-5-10-19(16)17/h4-10,14-15,18,20,33H,11-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,18+,20-/m0/s1
InChI key
WSJJYJNVFYARGB-CVAIRZPRSA-N
packaging【包装】
1 mg in glass bottle
安全信息
Pictograms【象形图】
GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H301
Precautionary Statements
P301 + P310 + P330
Hazard Classifications【危险分类】
Acute Tox. 3 Oral
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
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