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T3MG
产品别名
63088-04-0
T3MG
3MG
(±)-threo-3-Methylglutamic acid
threo-3-Methylglutamate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C6H11NO4 |
| Molecular weight | 161.16 |
| MDL number | MFCD09836097 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826708 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels. |
| Features and Benefits【特点和优势】 | This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
| Preparation Note【制备说明】 | T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml. |
产品性质
| Assay【测定】 | (single spot, TLC) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: >1.5 mg/dL |
| storage temp.【储存温度】 | room temp |
| SMILES string | C[C@@H](CC(O)=O)[C@@H](N)C(O)=O |
| InChI | 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1 |
| InChI key | FHJNAFIJPFGZRI-WVZVXSGGSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
