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Sulfo-LC-SDA (Sulfo-NHS-LC-Diazirine) (sulfosuccinimidyl 6-(4,4′-azipentanamido)hexanoate)

产品编号:3245786
包装规格:50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
324578650 MG6830
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C15H21N4NaO8S
Molecular weight
440.40
MDL number
MFCD28899432
PubChem Substance ID【PubChem化学物质编号】
329768799
NACRES
NA.22
General description【一般描述】
Succinimidyl-diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions, and these SDA reagents extend the efficiency and range of interactions that can be explored by this approach.
Features and Benefits【特点和优势】
  • Water soluble—solubility in aqueous solutions improved by a sulfonate group
  • Heterobifunctional—NHS ester group reacts with primary amines at pH 7 to 9 to form covalent amide bonds; diazirine (azipentanoate) group reacts efficiently with any amino acid side chain or peptide backbone upon activation with long-wave UV light (330-370 nm)
  • Controllable—two-step chemical crosslinking is activated using common laboratory UV lamps
  • Easy to use—these crosslinkers are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark
  • Better than aryl azides—the diazirine photoreactive group has better photostability in normal light than phenyl azide groups of traditional photoreactive crosslinkers, yet the diazirine group is more efficiently activated by long-wave UV light
Caution【注意】
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥90%
form【形式】
powder
mol wt【分子量】
440.4
reaction suitability
reagent type: cross-linking reagent
storage condition【储存条件】
desiccated
solubility【溶解性】
water: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
SMILES string
O=C(N1OC(CCCCCNC(CCC2(N=N2)C)=O)=O)CC(S(=O)([O-])=O)C1=O.[Na+]
InChI
1S/C15H22N4O8S.Na/c1-15(17-18-15)7-6-11(20)16-8-4-2-3-5-13(22)27-19-12(21)9-10(14(19)23)28(24,25)26;/h10H,2-9H2,1H3,(H,16,20)(H,24,25,26);/q;+1/p-1
InChI key
NZJSKWCJBUEDEO-UHFFFAOYSA-M
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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