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Sulfo-EGS (ethylene glycol bis(sulfosuccinimidyl succinate))

产品编号:3245783
包装规格:50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
324578350 MG2410
结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H18O18N2Na2S2
Molecular weight
660.45
MDL number
MFCD00054988
PubChem Substance ID【PubChem化学物质编号】
329768789
NACRES
NA.22
General description【一般描述】
EGS is a water-insoluble, homobifunctional N-hydroxysuccinimide ester (NHS ester) and Sulfo-EGS is its water-soluble analog. The spacer arm contains two cleavable ester sites that may be broken with hydroxylamine, which yields two fragments with terminal amide bonds and the release of ethylene glycol. These reagents are often used for conjugating radiolabeled ligands to cell surface receptors. The water insoluble reagent EGS does not possess a charged group, is lipophilic and, therefore, membrane-permeable and useful for intracellular and intramembrane protein conjugation. EGS is first dissolved in DMSO or DMF and added to the aqueous reaction mixture at a final solvent concentration of 10-20%, to minimize detrimental affects to the protein.
Features and Benefits【特点和优势】
  • Reactive groups: sulfo-NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Water-soluble; compare to EGS
  • Membrane-impermeable, allowing for cell surface labeling
  • Crosslinks formed are reversible at pH 8.5 using hydroxylamine for 3 to 6 hours at 37℃
  • Lactose dehydrogenase retained 60% of its activity after reversible crosslinking with EGS
Caution【注意】
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
产品性质
form【形式】
powder
Quality Level【质量水平】
100
mol wt【分子量】
660.45
reaction suitability
reagent type: cross-linking reagent
storage condition【储存条件】
desiccated
solubility【溶解性】
water: soluble
shipped in【运输】
ambient
storage temp.【储存温度】
−20℃
InChI
1S/C18H20N2O18S2.2Na/c21-11-7-9(39(29,30)31)17(27)19(11)37-15(25)3-1-13(23)35-5-6-36-14(24)2-4-16(26)38-20-12(22)8-10(18(20)28)40(32,33)34;;/h9-10H,1-8H2,(H,29,30,31)(H,32,33,34);;/q;2*+1/p-2
InChI key
IYBKWXQWKPSYDT-UHFFFAOYSA-L
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315 - H319 - H335
Precautionary Statements
P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Classifications【危险分类】
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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