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SR 48692
产品别名
146362-70-1
SR 48692
2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
Meclinertant
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H31ClN4O5 |
| Molecular weight | 587.07 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825286 |
| NACRES | NA.77 |
| Application【应用】 | SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:
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| Biochem/physiol Actions【生化/生理作用】 | SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex. |
| Features and Benefits【特点和优势】 | This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: ≥2 mg/mL (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O |
| InChI | 1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40) |
| InChI key | DYLJVOXRWLXDIG-UHFFFAOYSA-N |
| Gene Information | human ... NTSR1(4923) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
