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SL327

产品编号:3240293
规格:≥98% (HPLC), Mixture of E & Z isomers, solid
CAS NO:305350-87-2
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
32402935 MG2240
324029325 MG5650
产品别名

305350-87-2

SL327

SL-327

α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile

SL 327

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C16H12F3N3S
Molecular weight
335.35
MDL number
MFCD06411432
PubChem Substance ID【PubChem化学物质编号】
329824537
NACRES
NA.77
Application【应用】
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).
Biochem/physiol Actions【生化/生理作用】
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
storage condition【储存条件】
desiccated
protect from light
color【颜色】
white to off-white
mp
127-128.2 ℃
solubility【溶解性】
DMSO: >10 mg/mL
H2O: insoluble
storage temp.【储存温度】
2-8℃
SMILES string
N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
InChI
1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChI key
JLOXTZFYJNCPIS-FYWRMAATSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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