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SD-208
| 产品编号： | 3217761 |
| 规格： | ≥98% (HPLC), powder |
| CAS NO： | 627536-09-8 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
627536-09-8
SD-208
2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H10ClFN6 |
| Molecular weight | 352.75 |
| MDL number | MFCD11519969 |
| PubChem Substance ID【PubChem化学物质编号】 | 24899731 |
| NACRES | NA.77 |
| Application【应用】 | SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2 |
| Biochem/physiol Actions【生化/生理作用】 | SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1 SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to tan |
| solubility【溶解性】 | DMSO: >5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2 |
| InChI | 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) |
| InChI key | BERLXWPRSBJFHO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
