SB-3CT

C₁₅H₁₄O₃S₂

306.40

MFCD09836266

329824474

NA.77

SB−3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.

SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).

Sold under license of U.S. Patent 6,703,415.

100

≥98% (HPLC)

powder

desiccated

white to off-white

DMSO: >20 mg/mL

−20℃

O=S(=O)(CC1CS1)c2ccc(Oc3ccccc3)cc2

1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2

LSONWRHLFZYHIN-UHFFFAOYSA-N

5, 25 mg in glass bottle

11 - Combustible Solids

WGK 3