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SB 415286
产品别名
264218-23-7
SB 415286
3-[(3-Chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H10N3O5Cl |
| Molecular weight | 359.72 |
| MDL number | MFCD04039789 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278412 |
| Application【应用】 | SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation. |
| Biochem/physiol Actions【生化/生理作用】 | SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents. Glycogen synthase kinase-3 (GSK-3) inhibitor. |
| Features and Benefits【特点和优势】 | This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from GlaxoSmithKline. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| color【颜色】 | yellow to orange |
| solubility【溶解性】 | DMSO: 5 mg/mL, clear H2O: insoluble |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl |
| InChI | 1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23) |
| InChI key | PQCXVIPXISBFPN-UHFFFAOYSA-N |
| Gene Information | human ... GSK3A(2931), GSK3B(2932) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
