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SB 204741
产品别名
152239-46-8
SB 204741
N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H14N4OS |
| Molecular weight | 286.35 |
| MDL number | MFCD00923644 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278321 |
| NACRES | NA.77 |
| Application【应用】 | SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
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| Biochem/physiol Actions【生化/生理作用】 | SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses. 5-HT2B serotonin receptor antagonist. |
| Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from GlaxoSmithKline |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white to tan |
| solubility【溶解性】 | DMSO: soluble >20 mg/mL |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1 |
| InChI | 1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19) |
| InChI key | USFUFHFQWXDVMH-UHFFFAOYSA-N |
| Gene Information | human ... DRD2(1813), DRD3(1814), DRD5(1816), HTR1E(3354), HTR2A(3356), HTR2B(3357), HTR2C(3358) rat ... Adra1a(29412), Gabra2(29706), Htr1a(24473), Htr2b(29581), Htr3a(79246) |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
