您的位置：首页 > 产品中心 > Progranulin mouse
Progranulin mouse
| 产品编号： | 3208235 |
| 规格： | recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE) |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Progranulin mouse
PEPI
Proepithelin
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. |
| Physical form【外形】 | Solution in PBS. |
| Other Notes【其他说明】 | Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG®-tag. |
| Legal Information【法律信息】 | FLAG is a registered trademark of sigma-aldrich Co. LLC |
产品性质
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in HEK 293 cells |
| tag【标签】 | FLAG® tagged |
| Assay【测定】 | >95% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | ~70 kDa by SDS-PAGE |
| packaging【包装】 | pkg of 10 μg |
| manufacturer/tradename | sigma-aldrich |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| concentration【浓度】 | ≥0.2 mg/mL |
| impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
| color【颜色】 | clear |
| UniProt accession no.【UniProt登记号】 | P28798 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Grn(14824) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
