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OG-L002 hydrochloride

产品编号:3177262
规格:≥98% (HPLC)
CAS NO:1357299-45-6
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
31772625 MG2500
317726225 MG7320
产品别名

1357299-45-6

OG-L002 hydrochloride

4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C15H15NO · HCl
Molecular weight
261.75
PubChem Substance ID【PubChem化学物质编号】
329825831
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
OG-L002 is a recently developed inhibitor with IC50 of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
color【颜色】
, light yellow to dark orange
solubility【溶解性】
DMSO: 20 mg/mL, clear
storage temp.【储存温度】
2-8℃
SMILES string
N[C@@H]1[C@@H](C(C=C2)=CC=C2C3=CC=CC(O)=C3)C1.Cl
InChI
1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1
InChI key
LPVCAMIPTMRRLZ-LIOBNPLQSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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