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NSC 663284

产品编号:3176074
规格:≥98% (HPLC), solid
CAS NO:383907-43-5
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
31760745 MG3040
317607425 MG8810
产品别名

383907-43-5

NSC 663284

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C15H16ClN3O3
Molecular weight
321.76
MDL number
MFCD08276924
PubChem Substance ID【PubChem化学物质编号】
24724556
NACRES
NA.77
Application【应用】
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
Biochem/physiol Actions【生化/生理作用】
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
storage condition【储存条件】
protect from light
color【颜色】
red
solubility【溶解性】
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.【储存温度】
2-8℃
SMILES string
ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChI key
BMKPVDQDJQWBPD-UHFFFAOYSA-N
Gene Information
human ... CDC25B(994), DUSP3(1845), PTPN1(5770)
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)【闪点(F)】
470.1 °F
Flash Point(C)【闪点(C)】
243.4 ℃
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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