Monoclonal Anti-Spectrin (α and β) antibody produced in mouse

MFCD00164739

NA.41

Spectrins are heterotetramers, that are composed of several αand β subunit isoforms. They are the constituents of G-protein-coupled receptor (GPCR) and the synaptic multiprotein complex. α-Spectrin has 20 spectrin repeats (α1-α20) and β-spectrin has 17 spectrin repeats (β1-β17). SPTA1 (spectrin α 1) is located on chromosome 1q21–q23 and SPTB (spectrin β) is located on chromosome 14q22–q23.2.
Monoclonal anti-Spectrin (α and β) (mouse IgG1 isotype) is produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass.

This antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

human erythrocyte spectrin.

Anti-Spectrin (α and β) antibody has been used in western blotting and immunostaining.
Monoclonal Anti-Spectrin (α and β) antibody produced in mouse has been used in flow cytometry analysis and confocal microscopy.

Spectrins are multifunctional proteins, that modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β-spectrins are essential for the development of nervous system.

200

mouse

unconjugated

ascites fluid

primary antibodies

SB-SP1, monoclonal

15 mM sodium azide

human

indirect immunofluorescence: suitable using erythrocyte smears
microarray: suitable
western blot: 1:500 using extract of human erythrocyte ghosts or purified human erythrocyte spectrin

IgG1

P02549
P11277

dry ice

−20℃

human ... SPTA1(6708), SPTB(6710)

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12 - Non Combustible Liquids

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