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Anti-Sox2 antibody, Mouse monoclonal
| 产品编号： | 3152550 |
| 规格： | clone SOX2-6, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Sox2 antibody, Mouse monoclonal
Anti-SRY (sex determining region Y)-box 2
Anti-Sex-determining region Y-box 2
Anti-ANOP3
Anti-MCOPS3
Anti-SRY-related HMG-box gene 2
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-SOX2 (mouse IgG1 isotype) is derived from the hybridoma SOX2-6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acid. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3. |
| Application【应用】 | Anti-Sox2 antibody has been used in western blotting and immunohistochemistry. |
| Biochem/physiol Actions【生化/生理作用】 | Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | SOX2-6, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~35 kDa |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | western blot: 0.5-1.0 μg/mL using whole extract of human NT2 cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P48431 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SOX2(6657) mouse ... Sox2(20674) rat ... Sox2(499593) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
