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Anti-MRP2 antibody, Mouse monoclonal
| 产品编号： | 3148646 |
| 规格： | clone CPR96, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-MRP2 antibody, Mouse monoclonal
Anti-cMRP
Anti-ABCC2
Anti-CMOAT
Anti-Multidrug Resistance Associated Protein 2
基本信息
| MDL number | MFCD01865475 |
| NACRES | NA.41 |
| General description【一般描述】 | Anti-MRP2 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the CPR96 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptideintestine. The gene MRP2 (Multidrug Resistance-associated Protein 2), also referred to as ABCC2 (ATP binding cassette subfamily C member 2), encodes a glycosylated protein belonging to the subfamily of MRP efflux pumps, the members of which are localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule epithelia, and intestinal epithelia. The protein consists of 1545 aa residues having a molar mass of ∼190 kDa. The gene with 32 exons is mapped to human chromosome 10q24. |
| Application【应用】 | Anti-MRP2 antibody, Mouse monoclonal has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | The gene MRP2 (Multidrug Resistance-associated Protein 2) encodes a protein involved in organic anion efflux. It is involved in biliary transport and the efflux of many conjugated compounds across the apical membrane of the hepatocyte into the bile canaliculi. It also participates in multi-drug resistance in mammalian cells. Mutations in this gene have been associated with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by an increased concentration of bilirubin glucuronosides in blood. Multidrug Resistance-associated Protein 2 (MRP2) contributes to bile flow and plays a detoxification role and provides protection against oxidative stress. Upregulation of MRP2 expression may be found in hepatocellular carcinomas. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | CPR96, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~180 kDa |
| species reactivity | human |
| concentration【浓度】 | ~1.5 mg/mL |
| technique(s) | indirect ELISA: suitable microarray: suitable western blot: 1-2 μg/mL using cell extracts of 293T cells transfected with human MRP2 |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | Q92887 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ABCC2(1244) |
| packaging【包装】 | 200 μL in glass bottle |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
