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Monoclonal Anti-MDC1 antibody produced in mouse

产品编号:3148285
规格:clone P2B11, 1 mg/mL, purified immunoglobulin
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3148285100 μG5040
产品别名

Monoclonal Anti-MDC1 antibody produced in mouse

Anti-Nuclear factor with BRCT domains1

Anti-MDC1, P2B11

Anti-mediator of DNA damage checkpoint 1

基本信息
NACRES
NA.41
General description【一般描述】
Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.
Specificity【特异性】
Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.
Immunogen【免疫原】
GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius
Biochem/physiol Actions【生化/生理作用】
Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
产品性质
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
P2B11, monoclonal
form【形式】
buffered aqueous glycerol solution
mol wt【分子量】
antigen predicted mol wt 184 kDa
species reactivity
human, bovine, mouse, chimpanzee
concentration【浓度】
1 mg/mL
technique(s)
indirect immunofluorescence: suitable
western blot: suitable
isotype【同位素/亚型】
IgG1
NCBI accession no.【NCBI登记号】
NP_001010833.2
UniProt accession no.【UniProt登记号】
Q14676
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
mouse ... MDC1(240087)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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