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Monoclonal Anti-MAP2K3, (N-terminal) antibody produced in mouse

产品编号:3148121
规格:clone 1D10, purified immunoglobulin, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3148121100 μG5040
产品别名

Monoclonal Anti-MAP2K3, (N-terminal) antibody produced in mouse

MKK3

PRKMK3

MAPKK3

MEK3

基本信息
NACRES
NA.41
General description【一般描述】
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. (provided by RefSeq)
Immunogen【免疫原】
MAP2K3 (AAH32478, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVN
Physical form【外形】
Solution in phosphate buffered saline, pH 7.4
产品性质
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
1D10, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~37 kDa
species reactivity
human
technique(s)
capture ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
BC032478
UniProt accession no.【UniProt登记号】
P46734
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... MAP2K3(5606)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 1
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