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Monoclonal Anti-MAP1b antibody produced in mouse

产品编号:3148107
规格:clone AA6, ascites fluid
包装规格:100 μL,0.2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3148107100 μL4570
31481070.2 ML6000
产品别名

Monoclonal Anti-MAP1b antibody produced in mouse

Anti-MAP1.2

Anti-MAP1X

Anti-MAP5

基本信息
MDL number
MFCD00164682
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-MAP1b (MAP5) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Microtubule-associated protein (MAP1B) is the major microtubule associated protein in developing brain which changes its expression during development. In the new born rat brain, it is a major component of microtubules but in the adult its level is ten-fold lower.
MAP1b is a microtubule associated protein that interacts with actin filaments. MAP1b regulates microtubule stabilization and the development of axons. It may also act as a scaffolding protein Addition of antibody to microtubule proteins before polymerization in immunoassays results in abnormally short (but otherwise morphologically normal) microtubules. Immunohistochemical staining of brain tissue with the product shows selective labeling of dendritic trees throughout the brain. Monoclonal Anti-MAP1b does not react with tubulin of other microtubule associated proteins.
Specificity【特异性】
Monoclonal Anti-MAP1b antibody is specific for MAP1b in humans, mice, rats, bovines, cats, hamsters and chickens. The antibody does not cross-react with other MAPs or tubulin. Addition of the antibody to microtubule proteins before polymerization results in abnormally short (but otherwise morphologically normal) microtubules. In immunohistochemical staining of brain tissue, the antibody shows selective labeling of neurons with stronger staining of axons, dendrites and cell bodies.
Immunogen【免疫原】
rat brain microtubule-associated proteins (MAPs)
Application【应用】
Monoclonal Anti-MAP1b antibody produced in mouse has been used in:
  • immunohistochemistry
  • immunostaining
  • fluorescence microscopy

Biochem/physiol Actions【生化/生理作用】
Microtubule-associated protein (MAP1B) is the first MAP to appear in growing axons during development as it is present from the first emergence of the nascent axon from the cell body. Monoclonal Anti-MAP1b may be used to study MAP expression and cytological localization both in tissues and cell lines, under different developmental and environmental circumstances.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
ascites fluid
antibody product type
primary antibodies
clone【克隆】
AA6, monoclonal
contains【包含】
15 mM sodium azide
species reactivity
chicken, bovine, human, mouse, hamster, rat, feline
technique(s)
microarray: suitable
western blot: 1:500 using a fresh total rat brain extract or an enriched microtubule protein preparation
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P46821
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... MAP1B(4131)
mouse ... Mtap1b(17755)
rat ... Map1b(29456)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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