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Monoclonal Anti-MAGE-1 小鼠抗

Monoclonal Anti-MAGE-1 antibody produced in mouse
产品编号:3148039
规格:~2 mg/mL, clone MA454, purified immunoglobulin, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3148039200 μL4730
产品别名

Monoclonal Anti-MAGE-1 小鼠抗

Monoclonal Anti-MAGE-1 antibody produced in mouse

Anti-Melanoma-associatiated antigen 1

基本信息
MDL number
MFCD03096998
NACRES
NA.41
General description【一般描述】
Melanoma-associatiated antigen 1 (MAGE-1) is part of the CG (cancer-germline) group of genes and is a tumor-specific antigen. MAGE-1 is a member of the MAGE-A family. MAGE-1 gene is localized on human chromosome Xq28. Monoclonal Anti-MAGE-1 (mouse IgG1 isotype) is derived from the hybridoma MA454 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-1.
Specificity【特异性】
The antibody does not recognize MAGE-2 and MAGE-3.
Immunogen【免疫原】
recombinant human MAGE-1.
Application【应用】
Monoclonal Anti-MAGE-1 antibody produced in mouse has been used in:
  • ELISA
  • immunoblotting
  • immunohistochemistry

Biochem/physiol Actions【生化/生理作用】
The melanoma antigen genes (MAGE) might play a key role in neural development and apoptosis. Expression of melanoma-associated antigen 1 (MAGE-1) in neoplastic cells depends on the binding of the transcription factor Ets to non-methylated cis regulatory sequences, located in its promoter. MAGE-1 expression is mediatedby the B and B′ domains of MAGE-A1 gene. Expression of MAGE-1A was induced in non MAGE-A1 expressing tumor cells once treated with demethylating reagent, 5-aza-2-(5DC). Melanoma-associatiated antigen 1 (MAGE-1) has been shown to be expressed in different types of cancers.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
MA454, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~46 kDa
species reactivity
human
packaging【包装】
antibody small pack of 25 μL
concentration【浓度】
~2 mg/mL
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 5-10 μg/mL using total cell extract of SKML37 cells
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P43355
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... MAGEA1(4100)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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