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Monoclonal Anti-KCNB1 antibody produced in mouse

产品编号:3147291
规格:clone S4-11, 1 mg/mL, purified immunoglobulin
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3147291100 μG5040
产品别名

Monoclonal Anti-KCNB1 antibody produced in mouse

Anti-Kv2.1, S4-11

Anti-Kv2.1

Anti-Kcnb1

Anti-Kcr1-1

Anti-Shab

Anti-DRK1PC

基本信息
NACRES
NA.41
General description【一般描述】
The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons.
Specificity【特异性】
Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1.
Immunogen【免疫原】
Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975.
Biochem/physiol Actions【生化/生理作用】
Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
产品性质
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
S4-11, monoclonal
form【形式】
buffered aqueous glycerol solution
mol wt【分子量】
antigen predicted mol wt 105-125 kDa
species reactivity
rat, monkey, human, mouse
concentration【浓度】
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG1
NCBI accession no.【NCBI登记号】
NP_037318
UniProt accession no.【UniProt登记号】
Q14721
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
rat ... Kcnb1(25736)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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