您的位置:首页 > 产品中心 > Monoclonal Anti-IRAK antibody produced in mouse
Monoclonal Anti-IRAK antibody produced in mouse
产品编号: | 3147103 |
规格: | clone 8F1A7, purified immunoglobulin, buffered aqueous solution |
包装规格: | 100 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Monoclonal Anti-IRAK antibody produced in mouse
Anti-IL-1-Receptor Associated Kinase
基本信息
MDL number | MFCD01092386 |
NACRES | NA.41 |
Immunogen【免疫原】 | raised against a recombinant protein corresponding to amino acids 618 - 712 of human IRAK. |
Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
Physical form【外形】 | Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide. |
产品性质
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 8F1A7, monoclonal |
form【形式】 | buffered aqueous solution |
species reactivity | mouse, human |
technique(s) | immunohistochemistry: suitable indirect ELISA: suitable western blot: suitable |
UniProt accession no.【UniProt登记号】 | P51617 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
产品说明
Target description【目标描述】 | Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF). |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |