您的位置：首页 > 产品中心 > Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse
Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse
| 产品编号： | 3147044 |
| 规格： | clone 409405, purified immunoglobulin, lyophilized powder |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse
Anti-IL1A
Anti-IL1
基本信息
| MDL number | MFCD00162513 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. The IL-1α precursor produced initially is cleaved by calpain to produce a 16 kDa propeptide and 17 kDa mature protein. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The propeptide has nuclear localization sequence that enables it to shuttle to nucleus and activate transcription of target genes. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation.Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis Monoclonal Anti-Interleukin-1a propeptide recognizes human Interleukin-1α propeptide. It does not cross-react with mature forms of mouse IL-1α or rabbit IL-1α. |
| Immunogen【免疫原】 | purified, E. coli-derived recombinant human interleukin-1α propeptide (aa 1-112). |
| Application【应用】 | Anti-interleukin 1α antibody is suitable for immunoblotting at a working concentration of 1-2 μg/ml. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 409405, monoclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | western blot: 1-2 μg/mL |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | P01583 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL1A(3552) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
