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Monoclonal Anti-hnRNP-Q antibody produced in mouse

产品编号:3146504
规格:clone 18E4, purified immunoglobulin, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3146504200 μL5040
产品别名

Monoclonal Anti-hnRNP-Q antibody produced in mouse

Anti-Heterogeneous Nuclear Ribonucleoprotein-Q

基本信息
MDL number
MFCD03845440
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-hnRNP-Q (mouse IgG1) is derived from the 18E4 hybridoma produced by the fusion of murine myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with recombinant human hnRNP-Q. Heterogeneous nuclear ribonucleoproteins-Q (hnRNP-Q) family of proteins consist of three proteins (Q1, 2, and 3) that are derived by alternative splicing from the same gene.
Specificity【特异性】
The hnRNP-Q and hnRNP-R antibodies share 83% homology.
Immunogen【免疫原】
recombinant human hnRNP-Q.
Application【应用】
Monoclonal Anti-hnRNP-Q antibody produced in mouse has been used in immunoblotting and immunofluorescence. It may be used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation and immunohistochemistry.
Biochem/physiol Actions【生化/生理作用】
Heterogeneous nuclear ribonucleoproteins (hnRNPs) act in several biological activities such as transcription, pre- mRNA processing, cytoplasmic mRNA translation and turnover. These proteins interact with the survival of motor neurons protein (SMN) that is mutated in patients with spinal muscular atrophy (SMA). Immunodepletion of hnRNP-Q proteins and their localization in spliceosomes, indicate their important role in splicing.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
18E4, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen 55-70 kDa
species reactivity
Xenopus, mouse, rat, canine, human, chicken, bovine
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using HeLa total cell extract
isotype【同位素/亚型】
IgG1
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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