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Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse
| 产品编号： | 3146501 |
| 规格： | clone 4F4, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse
Anti-Heterogeneous Nuclear Ribonucleoprotein-C1/C2
基本信息
| MDL number | MFCD06798703 |
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-hnRNP-C1/C2 (mouse IgG1isotype) is derived from the 4F4 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with RNPs eluted from oligo (dT) cellulose column. Heterogeneous nuclear ribonucleoproteins C1/C2 (HnRNP C1/C2) are synthesized from C2 protein by alternative splicing and have an additional13-amino-acids. It is localized in nucleus and has leucine zipper-like RNA-binding motif. The hnRNP-C proteins have a single ribonucleoprotein (RNP) motif RNA-binding domain (RBD) of 80 to 100 amino acid long. |
| Immunogen【免疫原】 | RNPs eluted from oligo (dT) cellulose column. |
| Application【应用】 | Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Heterogeneous nuclear ribonucleoproteins C1/C2(HnRNP C1/C2) is involved in protein translation, mRNA biogenesis and transport. The hnRNP-C proteins preferentially bind to uridine-rich RNA sequences. Oligomerization of the protein through leucine rich regions in its C-terminal end is important for RNA binding. Mutation of the hnRNPC gene is implicated in embryonic lethal phenotype. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4, and 15 mM sodium azide. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 4F4, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 41 kDa antigen 43 kDa |
| species reactivity | monkey, human, chicken, hamster |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable indirect ELISA: suitable microarray: suitable western blot: 0.1-0.2 μg/mL using HeLa cell nuclear extract |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P07910 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HNRNPC(3183) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
