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Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in rat
| 产品编号： | 3145901 |
| 规格： | clone 67604, purified immunoglobulin, lyophilized powder |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Granulocyte Colony Stimulating Factor antibody produced in rat
Anti-MGI-IG
Anti-Csf3
Anti-G-CSF
Anti-Csfg
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Mature myeloid cells are derived from bone-marrow derived precursor cells by the activity of three colony stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). The expression of G-CSF is the result of activation of pathways in response to tumor necrosis factor-α, LPS and toll-like receptor ligands. The pathways that induce the effects of G-CSF are PI3K, ERK1/2 and p38. The generation of neutrophils and induction of the circulation of hematopoietic stem cells from the bone marrow are the main functions of G-CSF. There are additional activities attributed to G-CSF such as neuroprotection, immunomodulation and generation of cardiac cells and dendritic cells. Large quantities of G-CSF are secreted in a variety of myeloid and non-myeloid cancers and rheumatoid arthritis Monoclonal anti-granulocyte colony stimulating factor recognizes mouse G-CSF. The antibody shows less than 0.06% cross-reactivity with recombinant human G-CSF. |
| Immunogen【免疫原】 | purified, recombinant mouse granulocyte colony stimulating factor, expressed in E. coli. |
| Application【应用】 | Anti-granulocyte colony stimulating factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA the recommended concentration range is 2-8 μg/ml. The antibody is also suitable for neutralization assays. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 67604, monoclonal |
| form【形式】 | lyophilized powder |
| species reactivity | mouse |
| technique(s) | capture ELISA: 2-8 μg/mL neutralization: suitable western blot: 1-2 μg/mL |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P09920 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Csf3(12985) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
