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Monoclonal Anti-GCN5L2 antibody produced in mouse

产品编号:3145518
规格:clone 4D3, purified immunoglobulin, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3145518100 μG4470
产品别名

Monoclonal Anti-GCN5L2 antibody produced in mouse

Anti-hGCN5

Anti-GCN5

Anti-MGC102791

Anti-GCN5 general control of amino-acid synthesis 5-like 2 (yeast)

基本信息
MDL number
MFCD03791929
NACRES
NA.41
General description【一般描述】
General control of amino acid synthesis protein 5-like2 (GCN5L2) also known as KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]GCN5L2 gene is located on human chromosome 17q21.2. This protein is expressed in ovaries.
Immunogen【免疫原】
GCN5L2 (AAH32743, 738 a.a. ~ 837 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
KNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
Biochem/physiol Actions【生化/生理作用】
General control of amino acid synthesis protein 5-like2 (GCN5L2) regulates periodontitis through acetylation of dickkopf-related protein 1 (DKK1). It regulates early region 1A (E1A) dependant transactivation of human adenovirus. The protein modulates osteogenic differentiation of mesenchymal stem cells by blocking NF-κB (nuclear factor-κB) signalling pathway. GCN5 interacts with (origin recognition complex subunit 5) Orc5 and improves the chromatin-opening function of Orc5.
Physical form【外形】
Solution in phosphate buffered saline, pH 7.4
Legal Information【法律信息】
GenBank is a registered trademark of United States Department of Health and Human Services
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
4D3, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype【同位素/亚型】
IgG2bκ
GenBank® accession no.
BC032743
UniProt accession no.【UniProt登记号】
Q92830
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... KAT2A(2648)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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