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Monoclonal Anti-FOXP3 antibody produced in mouse
产品别名
Monoclonal Anti-FOXP3 antibody produced in mouse
XPID
PIDX
AIID
IPEX
JM2
基本信息
NACRES | NA.41 |
General description【一般描述】 | Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4+CD25+ regulatory T-cell subsets. |
Immunogen【免疫原】 | Purified recombinant fragment of human Foxp3 expressed in E.coli. Mouse monoclonal antibody raised against Foxp3 |
Application【应用】 | Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC). |
Biochem/physiol Actions【生化/生理作用】 | Forkhead box P3 (FOXP3) plays an essential role in the development of CD4+CD25+ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA). |
Physical form【外形】 | Ascitic fluid containing 0.03% sodium azide. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | ascites fluid |
antibody product type | primary antibodies |
clone【克隆】 | 2A11G9, monoclonal |
species reactivity | mouse, human |
technique(s) | direct ELISA: 1:10,000 immunohistochemistry: 1:200-1:1,000 indirect immunofluorescence: 1:200-1:1,000 western blot: 1:500-1:2,000 |
isotype【同位素/亚型】 | IgG1 |
NCBI accession no.【NCBI登记号】 | NM_014009 |
UniProt accession no.【UniProt登记号】 | Q9BZS1 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... Foxp3(50943) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |