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Monoclonal Anti-E2F6 antibody produced in mouse

产品编号:3144363
规格:~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3144363200 μL4730
产品别名

Monoclonal Anti-E2F6 antibody produced in mouse

Anti-E2F transcription factor 6

Anti-E2F-6

产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
TFE61, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~35 kDa
species reactivity
human
concentration【浓度】
~1.0 mg/mL
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
O75461
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... E2F6(1876)
基本信息
General description【一般描述】
E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.
Immunogen【免疫原】
recombinant human E2F6 protein
Application【应用】
Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.
Biochem/physiol Actions【生化/生理作用】
The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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