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Monoclonal Anti-DYRK1A antibody produced in mouse

产品编号:3144339
规格:clone 7D10, purified immunoglobulin, buffered aqueous solution
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3144339100 μG5040
产品别名

Monoclonal Anti-DYRK1A antibody produced in mouse

Anti-HP86

Anti-DYRK

Anti-MNBH

Anti-dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Anti-DYRK1

Anti-MNB

基本信息
MDL number
MFCD01633306
NACRES
NA.41
General description【一般描述】
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5′ UTR or in the 3′ coding region. These variants encode at least five different isoforms. (provided by RefSeq)
Immunogen【免疫原】
DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
NQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
Physical form【外形】
Solution in phosphate buffered saline, pH 7.4
Legal Information【法律信息】
GenBank is a registered trademark of United States Department of Health and Human Services
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
7D10, monoclonal
form【形式】
buffered aqueous solution
species reactivity
mouse
technique(s)
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype【同位素/亚型】
IgG2bκ
GenBank® accession no.
NM_001396
UniProt accession no.【UniProt登记号】
Q61214
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... DYRK1A(1859)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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