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Monoclonal Anti-DYNLT3 antibody produced in mouse
产品编号: | 3144338 |
规格: | ~1.0 mg/mL, clone R1, purified immunoglobulin, buffered aqueous solution |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Monoclonal Anti-DYNLT3 antibody produced in mouse
Anti-TCTE1L
Anti-Dynein, light chain, Tctex-type-3
Anti-RP3
Anti-TCTEX1L
基本信息
NACRES | NA.41 |
General description【一般描述】 | Monoclonal Anti-DYNLT3 (mouse IgG2a isotype) is derived from the hybridoma R1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with rat dynein 3 light chain-myosin basic protein fusion protein. DYNLT3 belongs to the Tctex-light chain family. It is also known as rp3. DYNLT3 has been located in both the cytoplasm and the nucleus, in cell- and tissue-specific manners. The subunit binds to SATB1 complex and the activity of this complex is independent of the dynein motor. |
Immunogen【免疫原】 | rat dynein 3 light chain myosin basic protein fusion protein. |
Application【应用】 | Monoclonal Anti-DYNLT3 antibody produced in mouse has been used in immunoblotting and immunoprecipitation. |
Biochem/physiol Actions【生化/生理作用】 | Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT3 is a light chain subunit of the complex that binds to Bub3, a spindle checkpoint protein and is depleted from the kinetochore during chromosome alignment. It contributes to dynein cargo binding specificity as dynein binds directly to a component of the spindle checkpoint complex through this light chain. The interaction of the Herpes simplex virus capsid protein VP26 with dynein light chains facilitates the binding of the virus capsid to cytoplasmic dynein during cellular infection. |
Physical form【外形】 | 0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。 |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | R1, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~12.5 kDa |
species reactivity | human, rat |
concentration【浓度】 | ~1.0 mg/mL |
technique(s) | immunoprecipitation (IP) western blot: 2-4 μg/mL using rat brain S1 extract |
isotype【同位素/亚型】 | IgG2a |
UniProt accession no.【UniProt登记号】 | P51808 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... DYNLT3(6990) rat ... Dynlt3(363448) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | nwg |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |