Anti-CIITA antibody, Mouse monoclonal

MFCD01864254

NA.41

Monoclonal Anti-CIITA (mouse IgG1 isotype) is derived from the hybridoma 7-1H produced by the fusion of mouse myeloma cells (Sp20 cells) and splenocytes from BALB/c mice immunized with purified N-terminal recombinant CIITA, amino acids 1-350. CIITA is expressed constitutively in B lymphocytes and in immature dendritic cells, while in other cells its expression is induced by IFN-γ.

Monoclonal Anti-CIITA recognizes human1 and mouse † CIITA.
Class II transactivator protein (CIITA) protein contains an acidic region in its N-terminal with transactivation activity, that binds to proteins in the basal transcription machinery and to cAMP response element-binding protein (CREB)-binding protein (CBP). The protein contains motifs for nuclear translocation, GTP binding motif and C-terminal leucine-rich repeats. CIITA is expressed constitutively in B lymphocytes and in immature dendritic cells, while in other cells its expression is induced by IFN-γ .

The antibody may be used in immunoblotting (∼130 kDa) and immunocytochemistry.

Class II transactivator protein (CIITA) interacts with specific transcription factors and creates the appropriate transcriptional scaffold required for HLA-D gene expression.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

7-1H, monoclonal

buffered aqueous solution

antigen ~130 kDa

mouse, human

~2 mg/mL

immunocytochemistry: suitable
western blot: 2-4 μg/mL using total cell extract of Raji cells

IgG1

P33076

dry ice

−20℃

human ... CIITA(4261)
mouse ... Ciita(12265)

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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)