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Monoclonal Anti-CD36-FITC antibody produced in mouse
产品编号: | 3142626 |
规格: | clone CB38, purified immunoglobulin, buffered aqueous solution |
包装规格: | 100 TEST |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Monoclonal Anti-CD36-FITC antibody produced in mouse
Anti-GPIIIb
基本信息
NACRES | NA.44 |
General description【一般描述】 | Cluster of differentiation 36 (CD36) is an 88 kDa membrane transporter glycoprotein. It is also known as platelet glycoprotein IV or IIIb. CD36 is a class B scavenger receptor expressed in platelets, endothelial cells, adipocytes, skeletal muscle cells and monocytes/macrophages. In human chromosome, the gene CD36 is localized on 7q21.11. CD36 (fatty acid translocase, FAT) is an 85-113 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. |
Specificity【特异性】 | The antibody CB38 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5. |
Immunogen【免疫原】 | Human myeloid cells |
Application【应用】 | The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests. |
Biochem/physiol Actions【生化/生理作用】 | Cluster of differentiation 36 (CD36) is a receptor for various ligands and act as a signalling molecule. CD36 facilitates the uptake of fatty acids, cholesterol, cholesteryl esters, low and high density lipoproteins. CD36 is involved in fatty acid metabolism. Polymorphism associated with CD36 increases the free fatty acid levels in plasma leading to cardiovascular disease, and hypertension. Polymorphism in CD36 causes type 2 diabetes mellitus. CD36 is a high affinity receptor, which aids in dietary fat perception in the tongue. CD36 along with Toll like receptors (TLRs) aids in internalization of Plasmodium falciparum parasitized erythrocytes. Mutations leading to deficiency of CD36 increases the severity of malaria. CD36 is an inhibitor of lung cancer and the hypermethylation of CD36 leads to cancer progression. CD36, a receptor for thrombospondin. regulates ovarian angiogenesis. High expression of CD36 is implicated in polycystic ovarian syndrome (PCOS). |
Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
Physical form【外形】 | Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | FITC conjugate |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | CB38, monoclonal |
form【形式】 | buffered aqueous solution |
species reactivity | human |
technique(s) | flow cytometry: suitable |
isotype【同位素/亚型】 | IgG1 |
NCBI accession no.【NCBI登记号】 | NM_000072.3 |
UniProt accession no.【UniProt登记号】 | P16671 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | 2-8℃ |
Gene Information | human ... CD36(948) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |