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Monoclonal Anti-CD33-FITC antibody produced in mouse

产品编号:3142607
规格:clone WM53, purified immunoglobulin, buffered aqueous solution
包装规格:100 TEST
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3142607100 TEST4510
基本信息
NACRES
NA.44
General description【一般描述】
Myeloid cell surface antigen CD33, (cluster of differentiation 33) also known as SIGLEC3, siglecs (sialic acid binding Ig-like lectins) and GP67, belongs to the CD33-related SIGLEC gene family. It is a type 1 transmembrane protein and contains two immunoglobulin-like extracellular domains, a single transmembrane area and two intracellular inhibitory motifs. The CD33 gene is mapped to human chromosome 19q13.41.
The antibody WM53 reacts with CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Immunogen【免疫原】
Human AML cells
Application【应用】
The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial is sufficient for 100 tests.
Biochem/physiol Actions【生化/生理作用】
Association of CD33 (cluster of differentiation 33) with sialic acid-containing ligands causes suppression of proinflammatory pathways in monocytes and macrophages. It is mainly involved in anti-inflammatory signaling, cell adhesion and endocytosis functions. CD33 also works as a myeloid differentiation marker. Mutations in the CD33 gene are associated with Alzheimer′s disease susceptibility and acute myeloid leukemia treatment efficacy. In microglia, increase in the expression of CD33 decreases amyloid β peptide phagocytosis.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
FITC conjugate
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
WM53, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human, nonhuman primates
technique(s)
flow cytometry: suitable
isotype【同位素/亚型】
IgG1
NCBI accession no.【NCBI登记号】
NM_001082618.1
UniProt accession no.【UniProt登记号】
P20138
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
Gene Information
human ... CD33(945)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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