Monoclonal Anti-CD31 antibody produced in mouse

NA.41

The antibody MEM-05 reacts with CD31 (PECAM-1), a 130-140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
The cluster of differentiation 31 (CD31), also known as platelet and endothelial cell adhesion molecule 1 (PECAM1) gene, spanning 75kb, is mapped on the long arm of human chromosome 17. This gene codes for 130kDa protein, which belongs to the immunoglobulin (Ig) superfamily. It is a vital component of the endothelial cell intercellular junction. CD31 is expressed on the surface of circulating platelets, monocytes, neutrophils and selected T-cell subsets.

Leukocytes of patient suffering from LGL-type leukaemia

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Cluster of differentiation 31 (CD31) plays a crucial role in the adhesion cascade leading to leukocyte extravasation during the inflammatory process. The encoded protein is essential for leukocyte transmigration via intercellular junctions of vascular endothelial cells. Genetic polymorphism of the gene is associated with atherosclerotic events. CD31, is a membrane glycoprotein that facilitates both homophilic and heterophilic adhesion. CD31 is also implicated in angiogenesis.

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

100

mouse

unconjugated

purified immunoglobulin

primary antibodies

MEM-05, monoclonal

buffered aqueous solution

human

1 mg/mL

flow cytometry: suitable

IgG1

NM_000442.4

P16284

wet ice

2-8℃

human ... PECAM1(5175)

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12 - Non Combustible Liquids