Monoclonal Anti-CD19-Biotin antibody produced in mouse

NA.41

CD19 is transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

The antibody 4G7 reacts with CD19 (B4), a 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.

Human CCL (chronic lymphocytic leukemia) cells

The reagent is designed for Flow Cytometry analysis. working concentrations should be determined by the investigator.

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Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

100

mouse

biotin conjugate

purified immunoglobulin

primary antibodies

4G7, monoclonal

buffered aqueous solution

human

1 mg/mL

flow cytometry: suitable

IgG1

NM_001178098.1

P15391

wet ice

2-8℃

human ... CD19(930)

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12 - Non Combustible Liquids