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Monoclonal Anti-Caspase 7 antibody produced in rat
| 产品编号： | 3142164 |
| 规格： | clone 11E4, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 0.2 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD01633625 |
| NACRES | NA.41 |
| General description【一般描述】 | Caspase-7 is a apoptosis-related cysteine peptidase, commonly known as CASP7. It is a human protein encoded by the CASP7 gene. CASP7 is a member of the caspase (cysteine aspartate protease) family of proteins and is an executioner protein of apoptosis. |
| Immunogen【免疫原】 | recombinant p20 subunit of human caspase-7. |
| Application【应用】 | Monoclonal Anti-Caspase 7 antibody produced in rat is suitable for the following applications:
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| Biochem/physiol Actions【生化/生理作用】 | Caspase-3 and -7 plays a central role in the execution-phase of cell apoptosis. The gene for caspase 7 (also known as Mch3, CMH-1 and ICELAP3) encodes a “short” prodomain protein product of 35 kDa that belongs to the Ced3/ICE family of cysteine proteases. Caspase 7 undergoes acleavage upon activation by caspase-3, -9 and -10, and granzyme B, leading to p20 and p12 subunits. It is an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic Tlymphocyte- induced cell killing in vivo. Monoclonal antibodies reacting specifically with caspase 7 are useful tools for the study of protease networks involved in development and regulation and governing the life and death of cells and tissues. |
| Preparation Note【制备说明】 | The antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 11E4, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen (full length) 35 kDa antigen (subunit) 20 kDa |
| species reactivity | human |
| technique(s) | immunoprecipitation (IP): suitable microarray: suitable western blot: 2-4 μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells |
| isotype【同位素/亚型】 | IgG2a |
| UniProt accession no.【UniProt登记号】 | P55210 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CASP7(840) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
